Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CNTF
- Formulation
- Phosphate-buffered solution, pH 7.2.
- Preparation
- The anti-human CNTF antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF solution contains no preservative; handle under aseptic conditions. Do not freeze.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the inhibition of proliferation induced by human recombinant CNTF (400 ng/mL) on TF?1 human erythroleukemic cells. ND50 range: 0.2 – 1.0 mg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783353 (BioLegend Cat. No. 608503) AB_2783354 (BioLegend Cat. No. 608504)
Antigen Details
- Structure
- Homodimer
- Distribution
-
Astrocytes, microglia, hepatocytes, skeletal muscle, embryonic stem cells, and bone marrow stromal cells.
- Function
- Stimulates gene expression, along with cell survival or differentiation in neuronal cell types. It is a potent trophic factor for motor neurons. IL-1b, TNFα (TNF-α), and EGF induces the release of CNTF from astrocytes.
- Interaction
- Sensory, sympathethic, ciliary, motor neurons, microglia, retinal ganglion cells, adipocytes, and skeletal muscle cells.
- Ligand/Receptor
- Trimeric complex form by CNTF receptor-α(CNTFRα), LIF receptor (LIFR), and gp130/ CD130.
- Cell Type
- Astrocytes, Embryonic Stem Cells, Microglia
- Biology Area
- Cell Biology, Stem Cells
- Antigen References
-
- Negro A, et al. 1991. Eur. J. Biochem. 201:289.
- Bazan JF. 1991. Neuron 7:197.
- Davis S, et al. 1993. Science 260:1805.
- Plun-Favreau H, et al. 2001. EMBO J. 20:1692.
- Lin HW, et al. 2009. J Neuroinflammation 6:7.
- Wen R, et al. 2012. Prog. Retin. Eye Res. 31:136.
- Gene ID
- 1270 View all products for this Gene ID
- UniProt
- View information about CNTF on UniProt.org
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