Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Tau Phospho (Ser262) peptide conjugated to KLH.
- Purity
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- Formulation
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2728571 (BioLegend Cat. No. 849503) AB_2728572 (BioLegend Cat. No. 849504)
Antigen Details
- Structure
- Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
- Distribution
-
Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol. - Function
- Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- Interaction
- Tau interacts with Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, Alpha-synuclein
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Phospho-Proteins
- Antigen References
-
1. Augustinack JC, et al. 2002. Acta Neuropath. 103(1):26-35. PubMed.
2. Seubert P, et al. 1995. J Biol Chem 270(32):18917-22. PubMed.
3. Dong Y, et al. 2012. PLoS One 7(6):e39386. PubMed. - Gene ID
- 4137 View all products for this Gene ID
- UniProt
- View information about Tau Phospho Ser262 on UniProt.org
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