Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human CCL19
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of the chemotaxis induced by recombinant human CCL19 (0.1 ?g/mL) on mouse Baf3-hCCR7 transfectant chemoattractant cells. ND50 range: 0.1 - 1.0 μg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2820099 (BioLegend Cat. No. 612803) AB_2820100 (BioLegend Cat. No. 612804)
Antigen Details
- Structure
- Chemokine
- Distribution
-
CCL19 is expressed in the T cell zone of lymph nodes, in Peyer's patches by reticular cells, and in the spleen by stromal cells. CCL19 is expressed by endothelial cells in lymphatic venules.
- Function
- CCL19 chemoattracts na?ve T cells and maturing dendritic cells (DCs) into T zones of secondary lymphoid organs. CCL19 and CCL21 inhibit apoptosis in DCs.
- Interaction
- Thymocytes, activated T cells, na?ve CD4 and CD8, mature DCs, antigen-engaged B cells, fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA).
- Ligand/Receptor
- CCR7 (CD197)
- Cell Type
- B cells, Dendritic cells, Macrophages, T cells
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Rossi DL, et al. 1997. J. Immunol. 158:1033.
- Sánchez-Sánchez N, et al. 2004. Blood 104:619.
- Comerford I, et al. 2006. Eur. J. Immunol. 36:1904.
- Leick M, et al. 2009. Immunology 129:536.
- Le Nou?n C, et al. 2011. PLoS Pathog. 7:e1002105.
- Gene ID
- 6363 View all products for this Gene ID
- UniProt
- View information about CCL19 on UniProt.org
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