Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CCL27 (CTACK)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of the chemotaxis induced by recombinant human CCL27 (CTACK) (50 ng/mL) on mouse Baf3-hCCR10 transfectant chemoattractant cells. ND50 range: 0.05 - 0.8 ?g /mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2894526 (BioLegend Cat. No. 940303) AB_2894526 (BioLegend Cat. No. 940304)
Antigen Details
- Structure
- Chemokine
- Distribution
-
CCL27 is expressed in gonads, thymus, placenta and skin. CCL27 is expressed by keratinocytes, fibroblasts.
- Function
- CCL27 attracts CLA+ memory T cells to the skin. CCL27 mRNA is induced by TNF-α and IL-1 in keratinocytes, and this increase is down-regulated by IL-10. CCL27 expression is down-regulated in keratinocytes by EGF. CCL27 has important function in T cell-mediated skin inflammation, antitumor immune responses and neuroimmune communication with T cells during peripheral allergic inflammation.
- Interaction
- CLA+ memory T cells, melanocytes, dermal fibroblasts, dermal microvascular endothelial cells, skin-derived Langerhans cells, and plasmacytoid dendritic cells
- Ligand/Receptor
- CCR10
- Cell Type
- Astrocytes, Epithelial cells, Fibroblasts
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Morales J, et al. 1999. P Natl Acad Sci USA. 96:14470.
- Homey B, et al. 2000. J Immunol. 164:3465.
- Homey B, et al. 2002. Nature Med. 8:157.
- Okada N, et al. 2006. Cancer Gene Ther. 13:393.
- Pivarcsi A, et al. 2007. P Natl Acad Sci USA. 104:19055.
- Kai H, et al. 2011. Pathol Res Pract. 207:43.
- Gene ID
- 10850 View all products for this Gene ID
- UniProt
- View information about CCL27 on UniProt.org
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