Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Galectin-4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5?- 10??g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses- RRID
- AB_2876716 (BioLegend Cat. No. 397007) AB_2876716 (BioLegend Cat. No. 397008)
Antigen Details
- Structure
- Contains at least two distinct carbohydrate recognising domains (CRD).
- Distribution
-
It is expressed in oral mucosa, esophagus, gastrointestinal epithelium, and intestinal epithelial cell lines.
- Function
- Controls intestinal inflammation, intestinal epithelial wound healing, protein apical trafficking, and stabilizes adherens junctions and lipid rafts in the microvillus membrane.
- Interaction
- T cells and macrophages.
- Ligand/Receptor
- Galectin-4 binds to glycosphingolipids with 3-O-sulfated Gal residues and carcinoembryonic antigens.
- Cell Type
- Epithelial cells
- Biology Area
- Cancer Biomarkers, Immunology
- Antigen References
-
1. Rabinovich GA, et al. 2002. J Leuko Biol. 71:741.
2. Huflejt ME, Leffler H. 2004. Glycoconj J. 20:247.
3. Ideo H, et al. 2005. J Biol Chem. 6:4730-7.
4. Markova V, et al. 2006. Int J Mol Med. 18:65.
5. Paclik D, et al. 2008. Inflamm Bowel Dis. 14:1366.
6. Paclik D, et al. 2008. PLoS One 3(7):e2629.
7. Belo A, et al. 2013. PLoS One 8(6):e65957.
8. Houzelstein D, et al. 2013. J Histochem Cytochem. 61:348.
9. Viguier M, et al. 2014. Tissue Barriers 2:e29103.
10. Cai Z, et al. 2014. Cancer Sci. 105:1510. - Gene ID
- 3960 View all products for this Gene ID
- UniProt
- View information about Galectin-4 on UniProt.org
