Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human clusterin.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P, Direct ELISA - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 ?g/ml. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 2.0 - 10??g/ml. For Direct ELISA, the suggested use of this reagent is 20 ng/ml - 3.0 ?g/ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2650695 (BioLegend Cat. No. 848701) AB_2650696 (BioLegend Cat. No. 848702)
Antigen Details
- Structure
- Clusterin is a protein of 449 amino acids with a molecular mass of 52 kD.
- Distribution
-
Tissue distribution: Ubiquitously expressed.
Cellular distribution: Primarily extracellular in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Intracellular clusterin is primarily present in the endoplasmic reticulum, cytosol, mitochondrion, and nucleus. - Function
- Clusterin is involved in several biological processes including extra- and intracellular chaperone activity, pro- and anti-apoptotic properties, lipid transportation, cell clustering, modulation of NF-kappa-B transcriptional activity, and complement inhibition.
- Interaction
- HDL.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Complement, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Apolipoproteins
- Antigen References
-
1. Trougakos IP. 2013. Gerontology 59:514. PubMed
2. Rizzi F, Bettuzzi S. 2010. Endocr. Relat. Cancer 17:R1. PubMed
3. Desikan RS, et al. 2014. JAMA Neurol. 71:180. PubMed
4. Carver JA, et al. 2003. IUBMB Life. 55:661. PubMed - Gene ID
- 1191 View all products for this Gene ID
- UniProt
- View information about Clusterin on UniProt.org
