Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IL-11.
- Formulation
- Phosphate-buffered solution, pH 7.2.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing activity. The ND50 is 0.2 – 0.8 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2650725 (BioLegend Cat. No. 694203) AB_2650726 (BioLegend Cat. No. 694204)
Antigen Details
- Structure
- Cytokine
- Distribution
-
Epithelial, endothelial, keratinocytes, stromal, neuronal, fibroblasts, osteoclasts, and bone marrow stromal cells.
- Function
- IL-11 plays important roles in hemopoiesis, thrombopoiesis, megakaryocytopoiesis, and bone resorption; It regulates macrophage differentiation and confers mucosal protection after chemotherapy and radiation therapy.
- Interaction
- Hematopoietic cells, hepatocytes, adipocytes, neurons, osteoblasts, fibroblasts, and gastrointestinal epithelial cells.
- Ligand/Receptor
- Membrane bound or soluble IL-11Rα heterodimerize with gp130β.
- Cell Type
- Endothelial cells, Epithelial cells, Fibroblasts, Osteoclasts
- Biology Area
- Cell Biology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Putoczki T and Ernst M. 2010. J. Leuko. Biol. 88 1109.
2. Wilde MI and Faulds D. 1998. BioDrugs 10:159.
3. Barton VA, et al. 2000. J. Biol. Chem. 275:36197.
4. Robb L, et al. 1998. Nat. Med. 4:303.
5. Lemoli RM, et al. 1995. Br. J. Haematol. 91:319.
6. Elias JA, et al. 1994. J. Biol. Chem. 269:22261.
7. Chen Q, et al. 2005. J. Immunol. 174:2305. - Gene ID
- 3589 View all products for this Gene ID
- UniProt
- View information about IL-11 on UniProt.org
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