Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IL-3
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing activity. The ND50 is 0.3 – 1.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2650727 (BioLegend Cat. No. 694303) AB_2650728 (BioLegend Cat. No. 694304)
Antigen Details
- Structure
- Cytokine
- Distribution
-
Activated T cells, Th1, Th2, mast cells, eosinophils, keratinocytes, NK cells, and endothelial cells.
- Function
- IL-3 is a pleiotropic factor which promotes both self-renewal and differentiation of early multipotential progenitors and is involved in inducible hematopoiesis in response to infections.
- Interaction
- Erythroid cells, megakaryocytes, neutrophils, eosinophils, basophils, mast cells, monocytic lineages.
- Ligand/Receptor
- Heterodimer IL-3Rα (CD123) and a common β subunit (βc) that is shared with the IL-5R and GM-CSFR.
- Cell Type
- Endothelial cells, Eosinophils, Mast cells, NK cells, T cells, Th1, Th2
- Biology Area
- Cell Biology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Kitamura T, et al. 1989. J. Cell. Physiol. 140:323.
2. Kohno M, et al. 2005. Blood 105:2059.
3. Murphy JM, Young IG. 2006. Vitam. Horm. 74:1.
4. Kleemann R, et al. 2008. Cardiovasc. Res. 79:360.
5. Valent P, and Dahinden CA. 2010. Curr. Opin. Hematol. 17:60.
6. Mirza S, et al. 2010. J. Biol. Chem. 285:22370. - Gene ID
- 3562 View all products for this Gene ID
- UniProt
- View information about IL-3 on UniProt.org
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