Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human VEGF-121.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization. The ND50 is 25 - 100 ng/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2632761 (BioLegend Cat. No. 692203) AB_2632762 (BioLegend Cat. No. 692204)
Antigen Details
- Structure
- Homodimer.
- Function
- VEGFA is a key player in vasculogenesis, the formation of blood vessels from progenitor cells, as well as angiogenesis. The expression of the VEGFA gene is upregulated via hypoxia, estrogen, and NF-κB pathways. In addition VEGF is upregulated by PDGF-BB, P1GF, TGFβ1, IGF1, FGFs, HGF, TNFα, and IL-1. VEGFA induces proliferation and cell migration in endothelial cells and plays important roles during wound healing. Also, VEGF regulates hematopoietic stem cell survival.
- Interaction
- VEGFA interacts with vascular endothelial cells and monocytes/macrophages, which express VEGFR1. This interaction induces proliferation of endothelial cells and stimulates migration of monocytes/macrophages.
- Ligand/Receptor
- VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1).
- Biology Area
- Angiogenesis, Cancer Biomarkers, Cell Biology, Cell Proliferation and Viability
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Conn G, et al. 1990. Proc. Natl. Acad. Sci. USA 87:1323.
2. Gerber H, et al. 2002. Nature 417:954.
3. Shibuya M, et al. 2006. J. Biochem. Mol. Biol. 39:469.
4. Shibuya M, et al. 2008. BMB Rep. 41:278.
5. Monaghan-Benson E, et al. 2010. The American Journal of Pathology 177:2091.
6. Koch S, Claesson-Welsh L. 2012. Cold Spring Harb. Perspect. Med. 2:a006502. - Gene ID
- 7422 View all products for this Gene ID
- UniProt
- View information about VEGF-121 on UniProt.org
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