Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human STAT6 peptide phosphorylated at Tyr641.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC, ChIP - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.01 - 0.05 ?g per ml. For immunocytochemistry, a concentration range of 0.2 - 1.0 μg/ml is recommended. For ChIP applications, the suggested dilution is 1:50-1:100 by volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody recognizes STAT6 Phospho (Tyr641) in all three isoforms at 74, 82, and 94 kD. The predominant band detected is at 94 kD.
- RRID
- AB_2715760 (BioLegend Cat. No. 690101) AB_2715760 (BioLegend Cat. No. 690102)
Antigen Details
- Structure
- 847 amino acids, predicted molecular weight of 94 kD. Contains a SH2 domain responsible for phosphor-Tyrosine binding and dimerization.
- Distribution
-
Translocates to the nucleus when phosphorylated.
- Function
- STAT6 is a transcription factor, mediating IL-4 and IL-13 signaling.
- Interaction
- STAT6 interacts with CBP/p300 and NCOA1. Forms a homodimer or a heterodimer with other STAT family members.
- Cell Type
- B cells
- Biology Area
- Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Nuclear Markers, Phospho-Proteins
- Antigen References
-
- Goenka S, et al. 2011. Immunol. Res. 50:87
- Wurster AL, et al. 2000. Oncogene. 19:2577
- Akira S, 1999. Stem Cells. 17:138
- Zamorano J, et al. 2005. J. Immunol. 174:2843
- David M, et al. 2001. Oncogene. 20:6660
- Takeda K, et al. 1996. Nature. 380:627
- Gene ID
- 6778 View all products for this Gene ID
- UniProt
- View information about STAT6 Phospho Tyr641 on UniProt.org
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