Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse TPO
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing activity. The ND50?is 0.04 – 0.2 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2687033 (BioLegend Cat. No. 696103) AB_2687034 (BioLegend Cat. No. 696104)
Antigen Details
- Structure
- Monomer
- Distribution
-
TPO is produced by liver and kidney.
- Function
- TPO regulates megakaryocytopoiesis and thrombopoiesis.
- Interaction
- Megakaryocytes
- Ligand/Receptor
- TPO-R (MPL, CD110)
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
1. Avanzi G, et al. 1988. Br. J. Haematol. 69:359.
2. Deutsch VR and Tomer A. 2006. Br. J. Haematol. 134:453.
3. Kaushansky K. 2005. J. Clin. Invest. 115:3339.
4. Li J, et al. 1999. Br. J. Haematol. 106:345.
5. Kato T, et al. 1997. Proc. Natl. Acad. Sci. 94:4669.
6. Ehrenreich H, et al. 2005. Proc. Natl. Acad. Sci. 102:862.
7. Sangkhae V, et al. 2014. Blood 124:3956. - Gene ID
- 22018 View all products for this Gene ID
- UniProt
- View information about Thrombopoietin on UniProt.org
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