Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human CCL8
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of the chemotaxis induced by recombinant human CCL8 (0.2 ?g/mL) on human THP-1 cells. ND50?range: 0.4 - 4 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2861115 (BioLegend Cat. No. 933203) AB_2861116 (BioLegend Cat. No. 933204)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Fibroblast, endothelial cells, monocytes, and macrophages
- Function
- CCL8 chemoattracts monocytes, T cells, NK cells, mast cells, eosinophils, and basophils. CCL8 is induced by IL-1β, IFNβ, INFγ, dsRNA, virus, ConA, and anti-CD2. The induction of CCL8 by IFNγ synergizes with the TLR ligands peptidoglycan (TLR2), dsRNA (TLR3), and LPS (TLR4).
- Interaction
- Monocytes, T cells, NK cells, mast cells, eosinophils, and basophils
- Ligand/Receptor
- CCR1 (CD191), CCR2 (CD192), CCR3 (CD193), and CCR5 (CD195)
- Cell Type
- Basophils, Eosinophils, Mast cells, Monocytes, NK cells, T cells
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Van Damme J, et al. 1992. J Exp Med. 176:59-65.
- Proost P, et al. 1998. J Immunol. 160:4034-41.
- Dean RA, et al. 2008. Blood. 112: 3455-64.
- Hori T, et al. 2008. Blood. 111:4403-12.
- Rom S, et al. 2010. FASEB J. 24:2292-300.
- Struyf S, et al. 2009. Eur J Immunol. 39:843-57.
- Islam SA, et al. 2011. Nat Immunol. 12:167-77.
- Gene ID
- 6355 View all products for this Gene ID
- UniProt
- View information about CCL8 on UniProt.org
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