Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human TIGIT
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by binding assay. Recombinant human TIGIT (grey dots, Cat. No. 788602) binds to immobilized recombinant human CD155 (at 2 ?g/mL) in a dose-dependent manner. Anti human TIGIT (clone A15153A, purple dots) inhibits the binding of human TIGIT (at 200 ng/mL) to human CD155 in a dose-dependent manner. ND50 range:? 50 – 250 ng/mL. It is recommended that the reagent be titrated for optimal performance for each application
- RRID
- AB_2820101 (BioLegend Cat. No. 613703) AB_2820102 (BioLegend Cat. No. 613704)
Antigen Details
- Structure
- Homodimer
- Distribution
-
Human follicular B helper T cells (TFH), regulatory, memory and activated T cells, NK cells
- Function
- Immunosuppressive effects by binding CD115 and modulating cytokine production by DC. Inhibits NK cell cytotoxicity. Inhibits T cell functions by competing with CD226. Tregs TIGIT+ cells suppress proinflammatory Th1 and Th17 cell, but not Th2 cell responses.
- Interaction
- Dendritic cells, monocytes
- Ligand/Receptor
- Poliovirus receptor (PVR/CD155) and nectin-2 (PRR-2/CD112)
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- Adhesion Molecules, Immune Checkpoint Receptors, Soluble Receptors
- Gene ID
- 201633 View all products for this Gene ID
- UniProt
- View information about TIGIT on UniProt.org
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