Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IL-32α
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone A15159A does not cross-react with mouse (in-house tested).
- RRID
- AB_2650733 (BioLegend Cat. No. 694702)
Antigen Details
- Structure
- 131 amino acids with a predicted molecular weight of 15 kD.
- Distribution
- Secreted by T cells, natural killer cells, dendritic cells, and keratinocytes.
- Function
- IL-32α expression can be induced by IL-18, IL-1β, IFN-γ, IL-12 and IL-17. The activity of IL-32α can be significantly increased by limited cleavage of IL-32α by neutrophil proteinase 3.
- Interaction
- IL-32α has been reported to interact with neutrophil proteinase 3, PKC, STAT3, integrin and paxilin.
- Cell Type
- T cells, NK cells, Dendritic cells
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Joosten LA, et al. 2013. Cell. Mol. Life Sci. 70:3883.
2. Kang JW, et al. 2012. J. Biol. Chem. 287:35556.
3. Cheon S, et al. 2011. J. Biol. Chem. 286:12049.
4. Nishida A, et al. 2009. J. Biol. Chem. 284:17868.
5. Heinhuis B, et al. 2012. J. Biol. Chem. 287:5733.
6. Novick D, et al. 2006. Proc. Natl. Acad. Sci. USA 103:3316.
7. Shioya M, et al. 2007. Clin. Exp. Immunol. 149:480. - Gene ID
- 9235 View all products for this Gene ID
- UniProt
- View information about IL-32alpha on UniProt.org
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