Product Details
- Verified Reactivity
- Human, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- KLH conjugated synthetic peptide corresponding to amino acid residues 70-78 of human neurogranin protein.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ELISA Capture, IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2650691 (BioLegend Cat. No. 848501) AB_2650692 (BioLegend Cat. No. 848502)
Antigen Details
- Structure
- Neurogranin is a 78 amino acid protein with a molecular mass of approximately 7.6 kD.
- Distribution
-
Tissue Distribution: Cerebral cortex neurons in layers II-VI, and pyramidal neurons.
Cellular distribution: Golgi apparatus, mitochondria, nucleus, and cytoplasm in neuronal cell body and dendrites. - Function
- Neurogranin is a neuron-specific, calmodulin-binding protein that participates in the protein kinase C signaling pathway. Neurogranin is a post-synaptic protein that modulates Ca2+ homeostasis in neurons by binding to and regulating the availability of calmodulin in the absence of Ca2+. Neurogranin function has been implicated in learning and memory.
- Ligand/Receptor
- Calmodulin.
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
- Molecular Family
- Postsynaptic proteins
- Antigen References
-
1. Diez-Guerra FJ. 2010. IUBMB Life. 62(8): 597. (PubMed)
2. De Vos A, et al. 2016. J Alzheimers Dis. 53(4): 1523. (PubMed)
3. De Vos A. et al. 2015. Alzheimers Dement. 11(12):1461. (PubMed) - Gene ID
- 4900 View all products for this Gene ID
