Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IL-1RL1, AA19-328
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume or 5 ?L per 100 ?L of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
- AB_2922608 (BioLegend Cat. No. 379403) AB_2922608 (BioLegend Cat. No. 379404)
Antigen Details
- Structure
- Single-pass type I membrane protein
- Distribution
-
Th2 lymphocytes, mast cells, eosinophils, basophils, smooth muscle cells, endothelial cells
- Function
- Cytokine signaling
- Interaction
- Signaling requires association of the coreceptor IL1RAP. Recruits MYD88, IRAK1, IRAK4, and TRAF6.
- Ligand/Receptor
- IL-33
- Cell Type
- Basophils, Endothelial cells, Eosinophils, Lymphocytes, NK cells, Th2, Tregs
- Biology Area
- Immunology
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
- Schmitz J, et al. 2005. Immunity. 23: 479-490.
- Brint E, et al. 2004. Nat Immun. 5:373-379.
- Griesenauer B, et al. 2017. Front Immunol. 8:475.
- Gene ID
- 9173 View all products for this Gene ID
- UniProt
- View information about IL-1RL1 on UniProt.org
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