Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human ZAP70 peptide phosphorylated at Tyr493
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1-0.5 ug/mL (1:1000-1:5000 dilution). It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2716044 (BioLegend Cat. No. 620101) AB_2716045 (BioLegend Cat. No. 620102)
Antigen Details
- Structure
- 619 amino acid protein with a predicted molecular weight of 70 kD. Contains 2 N-terminal SH2 domains and a C-terminal kinase domain.
- Distribution
-
T cells and NK cells
- Function
- Protein tyrosine kinase, T cell signaling
- Interaction
- CD247/CD3Z, NFAM1, SLA, , FCRL3, VAV1, CBL, RHOH, DEF6
- Cell Type
- NK cells, T cells
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Phospho-Proteins, Protein Kinases/Phosphatase
- Antigen References
-
- Katz ZB, et al. 2017. Nat Immunol.18:86.
- Klammt C, et al. 2015. Nat Immunol. 16:961.
- Jenkins MR, et al. 2014. eLife. 3:e01310
- Boldizsar F, et al. 2013. Mol Immunol. 53:111.
- Wu J, et al. 2006. J. Biol Chem. 281:11002.
- Kong G, et al. 1996. Mol. Cell. Biol. 16:5026.
- Wange RL, et al. 1995. J. Biol. Chem. 270:18730.
- Chan AC, et al. 1995. EMBO. J.14:2499.
- Gene ID
- 7535 View all products for this Gene ID
- UniProt
- View information about ZAP70 Phospho Tyr493 on UniProt.org
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