Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CCL11 (Eotaxin)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing the chemotaxis induced by recombinant human CCL11 (Eotaxin) (Cat. No. 583002) at 4 ng/mL on mouse Baf3-mCCR3 transfectant chemoattractant cells. ND50?range: 0.1 - 0.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2922630 (BioLegend Cat. No. 601753) AB_2922630 (BioLegend Cat. No. 601754)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Epithelial cells, smooth muscle cells, dendritic cells, and fibroblasts
- Function
- CCL11 selectively recruits eosinophils through binding to the chemokine receptor CCR3 during allergic response. CCL11 production is upregulated in response to several proimflammatory cytokines, such as IL-4, IL-13, TNF-α, and IFN-α, produced by mast cells and Th2 lymphocytes. CCL11 has been reported to stimulate eosinophil release from bone marrow, resulting in an elevated level of circulating eosinophils.
- Interaction
- Eosinophils
- Ligand/Receptor
- CCR3
- Cell Type
- Dendritic cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Conroy DM, et al. 2001. Respir Res. 2:150-6.
- Levina V, et al. 2009. Clin Cancer Res. 15:2647-56.
- Salcedo R, et al. 2001. J Immunol. 166:7571-8.
- Kaehler J, et al. 2006. J Investig Med. 54:446-54.
- Hadjicharalambous C, et al. 2004. J Allergy Clin Immunol. 113:657-62.
- Crump MP, et al. 1998. J Biol Chem. 273:22471-9.
- Gene ID
- 6356 View all products for this Gene ID
- UniProt
- View information about CCL11 on UniProt.org
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