Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CRP/PTX1
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 2.0 ?g per ml. For immunohistochemistry, a concentration range of 8?- 10??g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
For IHC-P, use 100 mM Tris, 10 mM EDTA, pH 9.0 for antigen retrieval buffer. Not recommended for use with Tris-buffered saline antigen retrieval buffer.
- RRID
- AB_2686984 (BioLegend Cat. No. 696006)
Antigen Details
- Structure
- Monomer and homopentamer
- Distribution
-
Hepatocytes
- Function
- Induces expression of E-selectin and VCAM-1 expression in epithelial cells. CRP binds to target, initiates, and regulates complement activation. Induced by IL-1 and IL-6.
- Interaction
- Phosphocholine on the surface of apoptotic cells
- Ligand/Receptor
- Interacts with C1q, bacterial polysaccharide, CD64, CD32, APCS (PTX2), HDL, leptin, and fibronectin.
- Biology Area
- Cell Biology
- Antigen References
-
1. Ansar W, Ghosh S. 2013. Immunol. Res. 56:131.
2. Agrawal A, et al. 2009. Adv. Exp. Med. Biol. 653:98.
3. Garlanda C, et al. 2005. Annu. Rev. Immunol. 23:337.
4. Verma S, et al. 2004. Circulation 109:1914.
5. Wadham C, et al. 2004. Circulation 109:2116.
6. Li XA, et al. 1998. Biochem. Biophys. Res. Commun. 244:249.
7. Lu J, et al. 2012. Immunol. Rev. 250:230.
8. Chen K, et al. 2006. Nat. Med. 12:425. - Gene ID
- 1401 View all products for this Gene ID
- UniProt
- View information about CRP on UniProt.org
