Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CXCL10 (IP-10)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing the chemotaxis induced by recombinant mouse CXCL10 (IP-10) (Cat. No. 573604) at 8 ng/mL on mouse Baf3- mCXCR3 transfectants. ND50 range: 0.6 - 3 ?g/mL.?It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2922639 (BioLegend Cat. No. 604453) AB_2922639 (BioLegend Cat. No. 604454)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Interferon gamma-stimulated keratinocytes, monocytes, macrophages, fibroblasts, endothelial, and T cells
- Function
- CXCL10 chemoattracts CD4, Th1, CD8, and NK and NKT cells. CXCL10 is induced by inflammatory cytokines. NH2-terminal cleavage of CXCL10 by DPP-IV/CD26 impairs its chemoattracting capacity and CXCR3 signaling ability.
- Interaction
- Activated T cells, Th1 cells, regulatory T cells, NK cells, NKT cells, endothelial cells, and fibroblasts
- Ligand/Receptor
- CXCR3
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Luster AD, et al. 1985. Nature 315:672-6.
- Vanguri P, et al. 1990. J. Biol. Chem. 265:15049-57.
- Loos T, et al. 2008. Blood 112:2648-56.
- Crawford MA, et al. 2009. Infect. Immun. 77:1664-78.
- Campanella GS, et al. 2010. PLoS One 5:e12700.
- Hoerning A. 2011. Eur. J. Immunol. 41:2291-302.
- Gene ID
- 15945 View all products for this Gene ID
- UniProt
- View information about CXCL10 on UniProt.org
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