Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human FAS
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Blocking - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking activity. The ND50?is 0.01– 0.05 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2716048 (BioLegend Cat. No. 684401) AB_2716055 (BioLegend Cat. No. 684402)
Antigen Details
- Structure
- Trimer
- Distribution
-
Activated human T cells, B cells, malignant human lymphoid cell lines, fibroblasts, dendritic cells, thymocytes, macrophages, cardiomyocytes, hepatocytes, FAS is expressed on most cell types.
- Function
- Apoptotic clearance of virus-infected cells, contributes to shutdown of chronic immune responses and to maintenance of peripheral tolerance. Soluble FAS modulates cell apoptosis.
- Interaction
- Lymphocytes T (mainly CD8+), NK cells.
- Ligand/Receptor
- FASL (TNFSF6)
- Cell Type
- T cells, B cells, Fibroblasts, Dendritic cells, Thymocytes, Macrophages
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Oehm A, et al. 1992. J Biol Chem. 267:10709.
2. Cheng J, et al. 1994. Science. 263:1759.
3. Papoff G, et al. 1996. J Immunol. 156:4622.
4. Rescigno M, et al. 2000. J Exp Med. 192:1661.
5. Giroux M, et al. 2005. Blood. 105:703.
6. Kovacic N, et al. 2010. Expert Opin Ther Targets 14:1121. - Gene ID
- 355 View all products for this Gene ID
- UniProt
- View information about CD95 on UniProt.org
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