Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human GDNF
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding between recombinant human GFRα1 and recombinant human GDNF (Cat. No. 760402). The ND50 range is 0.05 - 0.4 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2820112 (BioLegend Cat. No. 670903) AB_2820113 (BioLegend Cat. No. 670904)
Antigen Details
- Structure
- Disulfide-linked homodimer
- Distribution
-
GDNF is a secreted protein that is widely expressed in the developing and adult central nervous system.
- Function
- GDNF is a neurotrophic factor that promotes the development, differentiation, and the survival of dopaminergic neurons. It also participates in the recovery process after brain surgery.
- Interaction
- GDNF targets the neuronal cells expressing GDNF family receptors.
- Ligand/Receptor
- GDNF interacts with GDNF family receptor α-1 (GFRα1) and has a lower affinity with GFRα2, GFRα3, and GFRα4.
- Cell Type
- Embryonic Stem Cells, Mature Neurons, Neural Stem Cells, Neurons, Schwann Cells
- Biology Area
- Cell Biology, Neuroscience, Stem Cells, Synaptic Biology
- Molecular Family
- Growth Factors
- Antigen References
-
- Allen SJ, et al. 2013. Pharmacol Ther. 138:155.
- Hendrich J, et al. 2012. Neuroscience. 219:204.
- Hidalgo-Figueroa M, et al. 2012. J Neurosci. 32:864.
- Pascual A, et al. 2011. J Mol Endocrinol. 3:R83-92.
- Carnicella S, et al. 2009. Pharmacol Ther. 122:9.
- Sariola H, et al. 2003. J Cell Sci. 116:3855.
- Gene ID
- 2668 View all products for this Gene ID
- UniProt
- View information about GDNF on UniProt.org
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