Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Neurturin
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding between recombinant human GFRα2 and recombinant human Neurturin (Cat. No. 760304). The ND50 range is 0.2 - 5 μg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2861117 (BioLegend Cat. No. 935003) AB_2861118 (BioLegend Cat. No. 935004)
Antigen Details
- Structure
- Disulfide-linked homodimer
- Distribution
-
Neurturin is a secreted protein that is expressed in both neuronal tissues and non-neuronal tissues such as the pancreas, heart, and hair follicles.
- Function
- It is a neurotrophic factor and promotes the survival of sympathetic, nordose, and dorsal root ganglion sensory neurons.
- Interaction
- Neurturin targets multiple central and peripheral neurons including the midbrain dopaminergic, sympathetic, and sensory neurons.
- Ligand/Receptor
- Interacts with GDNF family receptor α-2 (GFRα2). Has a lower affinity with GFRα1.
- Cell Type
- Embryonic Stem Cells, Mature Neurons, Neural Stem Cells, Neurons
- Biology Area
- Cell Biology, Neuroscience, Stem Cells, Synaptic Biology
- Molecular Family
- Growth Factors
- Antigen References
-
- Kotzbauer PT, et al. 1996. Nature 6608:467-70.
- Doray B, et al. 1998. Hum. Mol. Genet. 7:1449-52.
- Milbrandt J, et al. 1998. Neuron 20:245-53.
- Baloh RH, et al. 1998. Neuron. 21:1291-302.
- Sariola H, Saarma M. 2003. 116:3855-3862.
- Ruiz-Ferrer M, et al. 2011. J. Mol. Med. (Berl) 5:471-80.
- Lindholm D, et al. 2016. Cell Mol. Life Sci. 7:1365-79.
- Gene ID
- 4902 View all products for this Gene ID
- UniProt
- View information about Neurturin on UniProt.org
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