Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CXCL2
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of the chemotaxis induced by recombinant human CXCL2 (Groβ) (1 ng/mL) on mouse Baf3-mCXCR2 transfectant chemoattractant cells. ND50 range: 0.2 - 1 ?g /mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2894458 (BioLegend Cat. No. 311001) AB_2894458 (BioLegend Cat. No. 311002)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Macrophages, monocytes, fibroblasts, and epithelial cells.
- Function
- CXCL2 chemoattracts and activates neutrophils, and it plays a key role in neutrophil mobilization from the bone marrow. CXCL2 is induced by TNFα, IL-1α, IL-17, and LPS.
- Interaction
- Neutrophils, basophils, lymphocytes, monocytes, keratinocytes, hematopoitic cells, endothelial cells, bone marrow endolthelial cells, osteoblasts, epithelial cells, fibroblasts, melanoma cells, melanocytes, and neurons
- Ligand/Receptor
- CXCR2
- Cell Type
- Epithelial cells, Fibroblasts, Monocytes
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Haskill S, et al. 1990. P. Natl. Acad. Sci. USA 87:7732.
2. De Plaen I, et al. 2006. Immunology 118: 153.
3. Carlson T, et al. 2008. J. Exp. Med. 205:811.
4. Eash KJ, et al. 2010. J. Clin. Invest. 120:2423.
5. Keeley EC, et al. 2011. Exp. Cell. Res. 317: 685.
6. Onishi RM and Gaffen SL, 2011. Immunology 129:311. - Gene ID
- 2920 View all products for this Gene ID
- UniProt
- View information about CXCL2 on UniProt.org
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