Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse TNFRSF17
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding of biotinylated recombinant mouse TNFRSF17 at 0.5 ?g/mL to immobilized recombinant mouse TNFSF13 at 0.5 ?g/mL. ND50 range: 0.2 - 1.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2892507 (BioLegend Cat. No. 943603) AB_2892507 (BioLegend Cat. No. 943604)
Antigen Details
- Structure
- CD Molecules
- Distribution
-
Resting and activated B cells, plasma blasts, plasma cells
- Function
- B cell maturation factor, maintains the peripheral B cell population and survival of long-lived bone marrow plasma cells, soluble BCMA acts as a decoy receptor for APRIL (TNFSFL13A).
- Interaction
- Associates with several TRAF family members, monocytes, macrophages, T cells, and dendritic cells
- Ligand/Receptor
- TNFSF13 (APRIL) and TNFSF (BAFF)
- Antigen References
-
- Madry C, et al. 1998. Int. Immunol. 10:1693.
- Hatzoglou A, et al. 2000. J. Immunol. 165:1322.
- Rennert P, et al. 2000. J. Exp. Med. 192:1677.
- Wallweber HJ, et al. 2004. J. Mol. Biol. 343:283.
- O'Connor BP, et al. 2004. J. Exp. Med. 199:91.
- Kim J, et al. 2011. Autoimmunity. 44:69.
- Coquery CM, Erickson LD. 2012. Crit. Rev. Immunol. 32:287.
- Laurent SA, et al. 2015. Nature Commun. 6:7333.
- Gene ID
- 21935 View all products for this Gene ID
- UniProt
- View information about CD269 on UniProt.org
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