Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- TTR-KLH peptide
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 1.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783454 (BioLegend Cat. No. 856301) AB_2783455 (BioLegend Cat. No. 856302)
Antigen Details
- Structure
- Transthyretin (TTR) is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 147 amino acids.
- Distribution
-
Primarily extracellular in blood and cerebrospinal fluid.
- Function
- The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
- Interaction
- Perlecan, receptor for advanced glycation end product (RAGE).
- Cell Sources
- Liver, choroid plexus epithelium, retina pigment epithelium.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Carrier Proteins
- Antigen References
-
- Groenning M. et al. 2015. Sci. Rep. 5:11443.
- Saelices L. et al. 2015. J. Biol Chem. 290, 28932-43.
- Gene ID
- 7276 View all products for this Gene ID
- UniProt
- View information about Transthyretin on UniProt.org
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