Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human β-NGF
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of the proliferation induced by recombinant human β-NGF (0.08 ?g/mL) on TF-1 human erythroleukemia cells. ND50 range: 0.1 - 0.8 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2814462 (BioLegend Cat. No. 617903) AB_2814463 (BioLegend Cat. No. 617904)
Antigen Details
- Structure
- Dimer
- Distribution
-
Hypothalamus, pituitary, thyroid gland, testes, epididymis, vascular smooth muscle cells, fibroblasts, myofibroblasts, mast cells, eosinophils.
- Function
- β-NGF is important for maintaining neuron homeostasis.
- Interaction
- Neurons, astrocytes, eosinophils, B, T, and mast cells.
- Ligand/Receptor
- Low-affinity NGF receptor (p75NTR); high-affinity NGF receptor (TrkA).
- Cell Type
- B cells, Eosinophils, Fibroblasts, Mast cells, Mature Neurons, Neural Stem Cells, Neurons, T cells
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Neurodegeneration, Neuroscience, Synaptic Biology
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
- Ullrich A, et al. 1983. Nature. 303:821.
- Klein R, et al. 1991. Cell. 65:189.
- Welker P, et al. 2000. Immunology 99:418.
- Fahnestock M, et al. 2004. Prog. Brain Res. 146:101.
- Bruno MA. Cuello AC. 2006. Proc. Natl. Acad. Sci. USA 103:6735.
- Aloe L, et al. 2015. Curr. Neuropharmacol. 13:294.
- Gene ID
- 4803 View all products for this Gene ID
- UniProt
- View information about beta-NGF on UniProt.org
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