Product Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Peptide from Human Stat5A phosphorylated at Tyr694
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume or 5 ?L per 100 ?L of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
This recombinant antibody clone is derived from clone A17016B. No changes or modifications were done to the antibody sequence or scaffold.
- RRID
- AB_2832912 (BioLegend Cat. No. 936903) AB_2832913 (BioLegend Cat. No. 936904)
Antigen Details
- Structure
- 794 amino acids, predicted molecular weight of 91 kD; contains a SH2 domains responsible for homodimerization or heterodimerization.
- Distribution
-
Cytoplasm; phosphorylated form translocates to the nucleus.
- Function
- STAT5 is a transcription regulator and is involved in cell differentiation, proliferation, and survival, in response to several cytokines, such as interleukins, erythropoietin, growth hormone, thrombopoietin, and prolactin.
- Antigen References
-
- Bell BD, et al. 2013. Nat. Immunol. 14:364.
- Cholez E, et al. 2012. Leukemia. 26:2390.
- Heltemes-Harris LM, et al. 2012. Curr. Opin. Immunol. 24:146.
- Heltemes-Harris LM, et al. 2011. Ann. N Y Acad. Sci. 1217:18.
- Malin S, et al. 2010. Curr. Opin. Immunol. 22:168.
- Xu J, et al. 2009. J. Neurosci. 29:2022.
- Gene ID
- 6776 View all products for this Gene ID
- UniProt
- View information about STAT5 Phospho Tyr694 on UniProt.org
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