Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human BACE1 protein.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
Direct ELISA - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. For ELISA Capture applications, a concentration range of 0.002 - 0.02 ?g/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2728601 (BioLegend Cat. No. 852901) AB_2728602 (BioLegend Cat. No. 852902)
Antigen Details
- Structure
- Human BACE1 is a 501 amino acid protein with a molecular mass of 56 kD and exists as 4 isoforms.
- Distribution
-
Tissue sources: Ubiquitously expressed. Highest levels in the brain and pancreas.
Cellular distribution: Plasma membrane, endoplasmic reticulum, and golgi apparatus. - Function
- BACE1 is involved in proteolytic processing of the amyloid precursor protein (APP). It cleaves APP at the N-terminus of the amyloid β peptide sequence, between residues 671 and 672 of APP.
- Interaction
- APP, IL1-R2, PSGL-1, ST6Gal-1, GGA1, GGA2, GGA3, RTN3, RTN4, SNX6, PCSK9, NAT8 and NAT8B.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Enzymes and Regulators, Secretases
- Antigen References
-
- Vassar R, et al. 2014. J. Neurochem. 130:4-28.
- Kandalepas PC, Vassar R. 2014. Curr. Alzheimers Res. 11:441-9.
- Kandalepas PC, Vassar R. 2012. J. Neurochem. 120(Suppl. 1):55-61.
- Gruninger-Leitch F, et al. 2002. J. Biol. Chem. 277:4687-93.
- Koelsch G. 2017. Molecules. 22(10): E1723.
- Gene ID
- 23621 View all products for this Gene ID
- UniProt
- View information about BACE1 on UniProt.org
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