Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic Claudin-1 peptide conjugated to KLH (TPRPYPKPAPSSGKDYVC)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone has no cross-reactivity with mouse (in house tested).
- RRID
- AB_2687205 (BioLegend Cat. No. 697801) AB_2687191 (BioLegend Cat. No. 697802)
Antigen Details
- Structure
- 211 amino acids with a predicted molecular weight of 22.7 kD and observed approximately 18kD. Multi-pass membrane protein with 4 transmembrane domains.
- Distribution
-
Cell membrane. Cell junction.
- Function
- Claudin-1 is an integral membrane protein that forms tight junctions between skin epithelial cells to form barriers, regulate paracellular transport, and maintain cell polarity.
- Interaction
- Forms homopolymers and heteropolymers with other claudin family proteins. Interacts with CLDN3, TJP1/ZO-1, TJP2/ZO-2, TJP3/ZO-3, MPDZ, and PATJ.
- Cell Type
- Mesenchymal Stem Cells
- Biology Area
- Stem Cells
- Antigen References
-
1. Suh Y, et al. 2017. Oncogene. 36:1167.
2. Tokumasu R, et al. 2016. Proc. Natl. Acad. Sci. USA. 113:E4061.
3. Zhou B, et al. 2015. J. Clin. Med. 4:1960.
4. Saeedi BJ, et al. 2015. Mol. Biol. Cell. 26:2252.
5. Huang J, et al. 2015. Oncotarget. 6:1652.
6. Izraely S, et al. 2015. Int. J. Cancer. 136:1296. - Gene ID
- 9076 View all products for this Gene ID
- UniProt
- View information about Claudin-1 on UniProt.org
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