Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783456 (BioLegend Cat. No. 856401) AB_2783457 (BioLegend Cat. No. 856402)
Antigen Details
- Structure
- VPS35 is a 796 amino acid protein with an apparent molecular mass of ~92 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed in all tissues.
Cellular Distribution: Cytosol, lysosome, endosome, and secreted. - Function
- Largest subunit of the retromer complex involved in retrograde transport of proteins from endosomes to the trans-Golgi network.
- Interaction
- VPS26 (VPS26A or VPS26B), VPS29, SNX1, SNX2, IGF2R, SNX3, GOLPH3, LRRK2, SLC11A2, SNX27, RAB7A.
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
- Molecular Family
- Organelle Markers
- Antigen References
-
- Cui Y, et al. 2018. FEBS Lett. 592(7):1096
- Williams ET, et al. 2017. J Parkinsons dis. 7(2):219
- Ferreira M, et al. 2017. Acta Neurol Scand. 135(3):273
- Gene ID
- 55737 View all products for this Gene ID 65114 View all products for this Gene ID 25479 View all products for this Gene ID
- UniProt
- View information about VPS35 on UniProt.org
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