Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human DOPA Decarboxylase (DDC) Protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 ?g/ml in human and 0.05 - 10??g/ml for mouse is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2814635 (BioLegend Cat. No. 869501) AB_2814636 (BioLegend Cat. No. 869502)
Antigen Details
- Structure
- DDC is a 510 amino acid protein with predicted and observed molecular mass of ~54 kD.
- Distribution
-
Tissue Distribution: Kidney, colon, adrenal gland, and brain
Cellular Distribution: Cytosol - Function
- DDC catalyzes several decarboxylation reactions in vivo including the conversion of DOPA to dopamine and 5-HTP to serotonin.
- Interaction
- DDC forms Homodimer.
- Cell Type
- Endothelial cells, Oligodendrocytes
- Biology Area
- Neurodegeneration, Neuroinflammation, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, Enzymes and Regulators
- Antigen References
-
- Himmelreich N, et al. 2019. Mol Genet Metab. 127(1):12
- Guenter J, et al. 2016. Postepy Hig Med Dosw. 70(0):1424
- Montioli R, et al. 2016. Curr Drug Metab. 17(5):513
- Gene ID
- 1644 View all products for this Gene ID 13195 View all products for this Gene ID
- UniProt
- View information about DOPA Decarboxylase on UniProt.org
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