Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 ?g per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2728585 (BioLegend Cat. No. 852001) AB_2728586 (BioLegend Cat. No. 852002)
Antigen Details
- Structure
- TFEB is a 476 amino acid protein with a molecular weight mass of approximately 53kD.
- Distribution
-
Tissue distribution: TFEB is expressed in numerous cell types of the central nervous system (CNS).
Cellular distribution: Cytosolic and nucleus.
- Function
- TFEB is a major regulator of autophagy and lysosomal biogenesis.
- Interaction
- TFEB interacts with the mTOR complex and its activity is thought to be regulated through the phosphorylation by mTOR.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
- Martini-Stoica H, et al. 2016. Trends Neurosci. 221-234.
- Napolitano G, Ballabio A. 2016. J. Cell Sci. 129: 2475-81.
- Raben N, Puertollano R. 2016. Annu. Rev. Cell Dev. Biol. 32: 255-278.
- Gene ID
- 7942 View all products for this Gene ID
- UniProt
- View information about TFEB on UniProt.org
我要詢價
*聯(lián)系方式：
(可以是QQ、MSN、電子郵箱、電話等，您的聯(lián)系方式不會被公開)
*內(nèi)容：
