Product Details
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- A synthetic peptide corresponding to TOMM40 protein.
- Formulation
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody shows negligible cross-reactivity with human TOMM40.
- RRID
- AB_2783433 (BioLegend Cat. No. 853603) AB_2783434 (BioLegend Cat. No. 853604)
Antigen Details
- Structure
- TOMM40 is a 361 amino acid protein with a molecular weight mass of ~40 kD.
- Distribution
-
Tissue distribution: TOMM40 is expressed in numerous tissues including the central nervous system (CNS), muscle, and the immune systems.
Cellular distribution: Cytosolic, mitochondria, and nucleus. - Function
- TOMM40 is the key subunit of the TOM complex, which imports proteins into the mitochondria.
- Interaction
- TOMM40 Interacts with mitochondrial targeting sequences and the TIM complex.
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance, Transcription Factors
- Molecular Family
- Mitochondrial Markers
- Antigen References
-
- Gottschalk WK, et al. 2014. J. Parkinsons Dis. Alzheimers Dis. 12.
- Shiota T, et al. 2015. Science 349:1544-8.
- Mise A, et al. 2017. J. Alzheimers Dis. 60:1107-1117.
- Ahting U, et al. 2001. J. Cell. Biol. 153:1151-60.
- Gene ID
- 10452 View all products for this Gene ID
- UniProt
- View information about TOMM40 on UniProt.org
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