Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human BMP-7
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of differentiation induced by recombinant human BMP-7 (Cat. No. 595602) at 0.2 ?g/mL on ATDC5 mouse chondrogenic cells. ND50 range: 0.3-1.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2894547 (BioLegend Cat. No. 946903) AB_2894547 (BioLegend Cat. No. 946904)
Antigen Details
- Structure
- Growth factor, homodimer
- Distribution
-
Widely expressed
- Function
- BMP-7 promotes bone formation; BMP-7 induces Langerhans cell differentiation and proliferation, induces brown adipocyte differentiation and thermogenesis, and it has antifibrotic properties.
- Interaction
- Osteoblasts, Langerhans cells, adipocytes, endothelial cells
- Ligand/Receptor
- BMP type-I receptor ALK3 and Type II BMP receptor
- Cell Type
- Embryonic Stem Cells, Hematopoietic stem and progenitors, Mesenchymal Stem Cells, Neural Stem Cells
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Neuroscience, Stem Cells, Synaptic Biology
- Molecular Family
- Cytokine/Chemokine Receptors, Growth Factors, Tumor Suppressors
- Antigen References
-
- Chen D, et al. 2004. Growth Factors 22:233.
- Tseng Y, et al. 2008. Nature 454:1000.
- Zeisberg E, et al. 2007. Nat. Med. 13:952.
- Hao ZM, et al. 2012. Mol. Ther. 20:2043.
- Yasmin N, et al. 2013. J. Exp. Med. 210:2597.
- Gene ID
- 655 View all products for this Gene ID
- UniProt
- View information about BMP-7 on UniProt.org
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