Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2814622 (BioLegend Cat. No. 868601)
Antigen Details
- Structure
- PAK1 is a 545 amino acid protein with predicted and observed molecular mass of ~61 kD.
- Distribution
-
Tissue distribution: Ubiquitously expressed in all tissues
Cellular distribution: Cytosol, plasma membrane, and nucleus - Function
- PAK1 plays an important role in regulating cytoskeletal dynamics, spine morphology, and synaptic plasticity.
- Interaction
- PAK1 forms homodimers, and interacts with: NISCH, DVL1, MUSK, CDC2L1, CDC2L2, p110C, CDC42/P21, RAC1, DSCAM, PDPK1, RAF1, NCK1, and NCK2.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability, Cell Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Cytoskeletal Proteins, Enzymes and Regulators, GPCR, Microtubules, Protein Kinases/Phosphatase
- Antigen References
-
- Xia S, et al. 2018. Small GTPases. 9(4):322
- Kreis P, et al. 2009. Cell Signal. 21(3):384
- Nikolic M. 2008. Mol Neurobiol. 37(2-3): 187
- Salminen A, et al. 2008. Biochem Biophys Res Commun. 371(4):587
- Gene ID
- 5058 View all products for this Gene ID 18479 View all products for this Gene ID 29431 View all products for this Gene ID
- UniProt
- View information about PAK1 on UniProt.org
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