Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human RAGE
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783446 (BioLegend Cat. No. 855901) AB_2783447 (BioLegend Cat. No. 855902)
Antigen Details
- Structure
- RAGE is a 404 amino acid protein with an apparent molecular mass of ~43 kD.
- Distribution
-
Tissue Distribution: Lung (major) and colon (less expressed)
Cellular Distribution: Plasma membrane, extracellular, and nucleus
- Function
- Functions as a pattern recognition receptor in the innate immune system that initiates proinflammatory responses.
- Interaction
- RAGE forms homo-dimers, and interacts with HMGB1, S100A1, APP, S100B, S100A12, and S100A14.
- Ligand/Receptor
- AGEs (advanced glycation end-products)
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Antigen References
-
- Barbezier N, et al. 2014. Ann. Biol. Clin. (Paris) 72:669.
- Kalea AZ, et al. 2009. Clin. Sci. (Lond) 116:621.
- Gene ID
- 177 View all products for this Gene ID
- UniProt
- View information about RAGE on UniProt.org
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