Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Galectin-2 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 0.1 - 1.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2783460 (BioLegend Cat. No. 856601) AB_2783461 (BioLegend Cat. No. 856602)
Antigen Details
- Structure
- Human Galectin-2 is a 132 amino acid protein with a molecular mass of ~15 kD.
- Distribution
-
Tissue distribution: Highly expressed in gastrointestinal tract, and to lesser extent in the immune system, kidney, and brain.
Cellular distribution: Cytosol.
- Function
- Galectin-2 his involved in immune cell homeostasis, inflammation, cell adhesion and protein trafficking. The protein levels of Galectin-2, and also other Galectin proteins, are significantly increased in colon and breast cancer patients, promoting cancer cell adhesion.
- Interaction
- Interactions: Glycans
Cellular targets: Interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) - Ligand/Receptor
- CD14, Toll-like receptor (TLR)-4 pathway, glycoconjugates
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience
- Molecular Family
- Adhesion Molecules
- Antigen References
-
- Delacour D, et al. 2009. Traffic. 10(10):1405-13.
- Barrow H, et al. 2011. Clin Cancer Res. 17(22):7035-46.
- Rabinovich G.A., et al. 2002. Trends Immunol. 23(6):313-20.
- Y?ld?r?m C. et al. 2015. PLoS One. 10(4):e0124347.
- Gene ID
- 3957 View all products for this Gene ID
- UniProt
- View information about Galectin-2 on UniProt.org
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