Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human PDGFRβ Recombinant Protein
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding between recombinant human PDGF-BB (Cat. No. 577306) and recombinant human PDGFRβ (Cat. No. 767206). The ND50 range is 0.08 – 0.6 μg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2814474 (BioLegend Cat. No. 622803) AB_2814475 (BioLegend Cat. No. 622804)
Antigen Details
- Structure
- Homodimer
- Distribution
-
Cells of mesenchymal origin, mesothelioma cell lines, pericytes and vascular smooth muscle cells.
- Function
- Proliferation, transformation, migration, survival, and apoptosis of mesenchymal cells, in development and pathogenesis. Development of hematopoietic/endothelial precursors, regulates craniofacial development.
- Interaction
- Interacts with a number of kinases (including Raf-1, NCK1, FAK, Fyn, others) as well as adaptor molecules and signaling intermediates (Grb2, Grb4, RasGAP, SHP2, SHC1, Crk, others). Has also been shown to associate with integrin β3 and nexin sorting.
- Cell Type
- Embryonic Stem Cells, Mesenchymal cells, Mesenchymal Stem Cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
- Tiesman J and Hart CE. 1993. J. Biol. Chem. 13:9621-8.
- Lindahl P, et al. 1997. Science 277:242.
- Hart CE, et al. 1998. Science. 240:1529.
- Borkham-Kamphorst E, et al. 2004 Lab Invest. 84:766.
- Lennartsson J, et al. 2006. J. Biol. Chem. 281:39152.
- Van den Akker NM, et al. 2008 Dev. Dyn. 237: 494.
- Toffalini F, Demoulin JB. 2010. Blood 116:2429.
- Shan H, et al. 2011. Cancer Sci. 102:1904.
- Demoulin JB, Montano-Almendras CP. 2012. Am. J. Blood Res. 2:44.
- Heldin CH, Lennartsson J. 2013. Cold Spring Harb. Perspect. Biol. 5:a009100.
- Weissmueller S, et al. 2014 Cell. 157:382.
- Fantauzzo KA, Soriano P. 2016. Genes Dev. 30:2443.
- Gene ID
- 5159 View all products for this Gene ID
- UniProt
- View information about CD140b on UniProt.org
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