Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human COMT
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
ICC, ICFC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 ?g/mL is suggested. For immunocytochemistry, a concentration range of 1.25 - 2.5 μg/mL is recommended.?For intracellular flow cytometric staining, the suggested concentration range?of this reagent is 0.01 - 0.03 ?g/test. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Product is not recommended for Western Blot.
For ICC, recommend fixation/permeabilization with 100% ice-cold methanol. Do not recommend fixation with 4% PFA.- RRID
- AB_2922640 (BioLegend Cat. No. 604551) AB_2922640 (BioLegend Cat. No. 604552)
Antigen Details
- Structure
- COMT is a 271 amino acid protein with a predicted molecular weight of 30.0 kD.
- Distribution
-
COMT can be found in the cytosol and on the plasma membrane.
- Function
- Methyltransferase
- Cell Type
- Dopaminergic Neurons, Mature Neurons, Neurons
- Biology Area
- Neurodegeneration, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
- Akhtar MJ, et al. 2020. Bioorg Chem. 94:103418.
- Scheggia D, et al. 2012. CNS Neurol Disord Drug Targets. 11:209-21.
- Hosak L. 2007. Eur Psychiatry. 22:276-81.
- Gene ID
- 1312 View all products for this Gene ID
- UniProt
- View information about COMT on UniProt.org
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