Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human BMP-10
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by the inhibition of proliferation induced by human recombinant BMP-10 (0.1 ?g/mL) on ATDC5 mouse chondrogenic cells. ND50 range: 4.0 -?20 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2814464 (BioLegend Cat. No. 618103) AB_2814465 (BioLegend Cat. No. 618104)
Antigen Details
- Structure
- Homodimer.
- Distribution
-
BMP-10 is abundant in developing and postnatal heart.
- Function
- BMP-10 has a critical role in heart development, modulates cardiomyocyte proliferation and maturation during cardiac ventricular development, and retinal postnatal vascularization. Myocardin, a transcriptional coactivator, regulates BMP-10 expression
- Interaction
- Endothelial cells.
- Ligand/Receptor
- Heterotretrameric receptor formed by two type I receptors (ALK1) and two type II receptors (BMPRII, ActRIIA, and ActRIIB). Endoglin is a correceptor for ALK1.
- Cell Type
- Endothelial cells
- Biology Area
- Cell Biology, Neuroscience, Stem Cells, Synaptic Biology
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
- Neuhaus H, et al. 1999. Mech. Dev. 80:181.
- David L, et al. 2007. Blood. 109:1953.
- Llorca O, et al. 2007. J. Mol. Biol. 365:694.
- Susan-Resiga D, et al. 2011. J. Biol. Chem. 286:22785.
- Ricard N, et al. 2012. Blood. 119:6162.
- Huang J, et al. 2012. J. Clin. Invest. 122:3678.
- Chen H, et al. 2013. Proc. Natl. Acad. Sci. USA. 29:11887.
- Tillet E and Bailly S. 2014. Front Genet. 5:456.
- Gene ID
- 27302 View all products for this Gene ID
- UniProt
- View information about BMP-10 on UniProt.org
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