Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CCL22
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing activity. The ND50 is 1.5 - 4.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2650729 (BioLegend Cat. No. 694403) AB_2650730 (BioLegend Cat. No. 694404)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Macrophages, NK cells, IFNγ stimulated human keratinocytes, thymic epithelial cells and intestinal epithelial cells.
- Function
- Induces the migration of CCR4+ Th2 cells, Tregs, DC, and NK cells. Induced by LPS and CD40 antibody in macrophages. Upregulated by Th2 cytokines (IL-4 and IL-5) and downregulated by Th1 cytokines (IFNγ).
- Interaction
- Dendritic cells, NK cells, Th2 cells, T regs, CLA+ skin-homing memory/effector T cells.
- Ligand/Receptor
- CCR4
- Cell Type
- Epithelial cells, Macrophages, NK cells
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Godiska R, et al. 1997. J. Exp. Med. 185:1595.
2. Imai T, et al. 1998. J. Biol. Chem. 273(3):1764-8.
3. Yamashita U and Kuroda E. 2002. Crit. Rev. Immunol. 22:105.
4. Horikawa T, et al. 2002. Int. Immunol. 14:767.
5. Mailloux AW, et al. 2009. J. Immunol. 182:2753.
6. Dogan RN, et al. 2011. J. Leukoc. Biol. 89:93.
7. Osborn O, et al. 2011. Cytokine 53:311. - Gene ID
- 6367 View all products for this Gene ID
- UniProt
- View information about CCL22 on UniProt.org
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