Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse TIGIT Recombinant Protein
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding between mCD155 / PVR and mTIGIT. The ND50 range: 0.01?– 0.06??g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2814472 (BioLegend Cat. No. 622203) AB_2814473 (BioLegend Cat. No. 622204)
Antigen Details
- Structure
- Homodimer
- Distribution
-
Human follicular B helper T cells (TFH), regulatory, memory and activated T cells, NK cells.
- Function
- Immunosuppressive effects by binding CD155 and modulating cytokine production by DC. Inhibits NK cell cytotoxicity. Inhibits T cell functions by competing with CD226. Tregs TIGIT+ cells suppress proinflammatory Th1 and Th17 cells, but not Th2 cell responses.
- Interaction
- Dendritic cells, monocytes
- Ligand/Receptor
- Poliovirus receptor (PVR/CD155) and nectin-2 (PRR-2/CD112)
- Cell Type
- NK cells, T cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Adhesion Molecules, Immune Checkpoint Receptors, Soluble Receptors
- Antigen References
-
- Yu X, et al. 2009. Nat. Immunol. 10:48.
- Stanietsky N, et al. 2009. Proc. Natl. Acad. Sci. U S A. 106:17858.
- Joller N, et al. 2011. J. Immunol. 186:1338.
- Tahara-Hanaoka S, et al. 2004. Int. Immunol. 16:533.
- Lozano E, et al. 2012. J. Immunol. 188:3869.
- Joller N, et al. 2014. Immunity. 40:569.
- Deuss FA, et al. 2017. J. Biol. Chem. 292:11413.
- Gene ID
- 100043314 View all products for this Gene ID
- UniProt
- View information about TIGIT on UniProt.org
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