Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human ataxin-2 recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 - 10 ?g per ml. For formalin-fixed paraffin-embedded immunohistochemical staining, a concentration range of 1 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2810809 (BioLegend Cat. No. 868001) AB_2810810 (BioLegend Cat. No. 868002)
Antigen Details
- Structure
- Human ataxin-2 is a 1,313 amino acid protein with a predicted molecular mass of 140 kD.
- Distribution
-
Tissue distribution: Brain, spinal cord, heart, liver, skeletal muscle, pancreas, and placenta
Cellular distribution: Cytoplasm - Function
- Ataxin-2 is involved in the RNA splicing, protein interactions, and metabolic homeostasis.
- Interaction
- Ataxin-2 interacts with TARDBP, RBFOX1, polyribosomes, SH3GL2, SH3GL3, SH3KBP1, CBL, EGFR, and ATXN2L.
- Cell Type
- Neurons
- Biology Area
- Neurodegeneration, Neuroscience, Synaptic Biology
- Antigen References
-
Carmo-Silva S, et al. 2017. Trends Endocrinol Metab. 28(4):309-318.
van den Heuvel DM, et al. 2014. Trends Mol Med. 20(1):25-35.
Becker LA, et al. 2017. Nature. 544(7650):367-371.
Scoles DR, et al. 2017. Nature. 544(7650):362-366 - Gene ID
- 6311 View all products for this Gene ID
- UniProt
- View information about Ataxin-2 on UniProt.org
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