Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic human SLP76 peptide containing phosphorylated Ser376
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone was tested for ICC on PFA-fixed and methanol permeabilized Jurkat cells treated with or without H2O2 and produced nuclear staining that was not responsive to the treatment. We therefore do not recommend this clone for ICC.
?cross-reactivity to Mouse confirmed based on Western blot testing.- RRID
- AB_2801128 (BioLegend Cat. No. 667101) AB_2801129 (BioLegend Cat. No. 667102)
Antigen Details
- Structure
- SLP76 is a 533 amino acid protein with a predicted molecular weight of ~60 kDa.
- Distribution
-
Hematopoietic cells/cytosol
- Function
- Adapter protein/TCR Signaling
- Interaction
- ITK, LAT, GRB2, PLCγ1, NCK, VAV, ITK, LCK, 14-3-3ε
- Cell Type
- B cells, Monocytes, NK cells, T cells
- Biology Area
- Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Phospho-Proteins, Protein Kinases/Phosphatase
- Antigen References
-
- Sauer K, et al. 2001. J Biol Chem. 276:45207.
- Koretzky GA, et al.. 2006. Nat Rev Immunol. 6:67.
- Di Bartolo V, et al. 2007. J Exp Med. 204:681.
- Lasserre, et al. 2011. J Cell Biol. 195:839.
- Gene ID
- 3937 View all products for this Gene ID
- UniProt
- View information about SLP76 Phospho Ser376 on UniProt.org
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