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Purified anti-RCAN1 Antibody

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Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human RCAN1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2814606 (BioLegend Cat. No. 866201) AB_2814607 (BioLegend Cat. No. 866202)

Antigen Details

Structure
RCAN1 is a 252 amino acid protein with predicted molecular mass of ~ 28 kD, and observed molecular masses of ~ 35 kD (RCAN1L) and ~24 kD (RCAN1S) by WB.
Distribution

Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Nucleus and Cytosol

Function
RCAN1 inhibits the calcineurin/NFAT signaling pathway
Interaction
RAF1, PPP3CA, PPP3R1, Calcineurin A
Cell Type
Microglia
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction, Synaptic Biology
Antigen References
  1. Porta S, et al. 2007. Hum Mol Genet. 16(9):1039
  2. Torac E, et al. 2014. J Med Life. 7(4):481
  3. Wu Y, et al. 2014, Mol Neurobiol. 50(3):1085
  4. Harris CD, et al. 2005. Cell Mol Life Sci. 62(21):2477
Gene ID
1827 View all products for this Gene ID 54720 View all products for this Gene ID 266766 View all products for this Gene ID
UniProt
View information about RCAN1 on UniProt.org
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