Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human NRAS a.a. 1-186
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. For immunohistochemistry, a concentration range of 2.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2810783 (BioLegend Cat. No. 866101) AB_2810784 (BioLegend Cat. No. 866102)
Antigen Details
- Structure
- NRAS is a 189 amino acid protein with predicted and observed molecular mass of ~ 21 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed. Highly expressed in appendix, gallbladder, and gastrointestinal tract.
Cellular Distribution: Plasma membrane, Golgi apparatus, cytosol, and nucleus. - Function
- G-Like regulatory protein that plays a role in regulating cell growth.
- Interaction
- RGS14, RASSF7
- Ligand/Receptor
- GTP, GDP
- Cell Type
- Astrocytes, Endothelial cells, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Oligodendrocytes
- Biology Area
- Cancer Biomarkers, Cell Biology, Cell Proliferation and Viability, Neuroscience, Stem Cells
- Molecular Family
- GTPases
- Antigen References
-
- Rocks O, et al. 2005. Science. 307:1746-52.
- Byrne M, Saif MW. 2019. Onco. Targets Ther. S194605
- Sexton RE, et al. 2019. Semin. Cancer Biol. 54:131-7.
- Gene ID
- 4893 View all products for this Gene ID 24605 View all products for this Gene ID
- UniProt
- View information about NRAS on UniProt.org
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