Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Rab8A
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 594 under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 2.0 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor? 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses- Application Notes
This clone cross-react with Rab8A and Rab8B.
- RRID
- AB_2820160 (BioLegend Cat. No. 865405) AB_2820161 (BioLegend Cat. No. 865406)
Antigen Details
- Structure
- Rab8 is a 207 amino acid protein with an apparent molecular mass of ~24 kD.
- Distribution
-
Tissue Distribution: ubiquitously expressed
Cellular Distribution: Plasma membrane, cytoskeleton, cytosol, Golgi Apparatus, and endosome. - Function
- Rab8 is a GTPase that plays an important role in intracellular membrane trafficking.
- Interaction
- MICALL1, MICALL2, Optineurin, MAP4K2
- Cell Type
- Astrocytes, Dopaminergic Neurons, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes
- Biology Area
- Cancer Biomarkers, Cell Biology, Cell Cycle/DNA Replication, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Synaptic Biology
- Molecular Family
- Autophagosome Markers, Cytoskeletal Proteins, Organelle Markers, Tumor Suppressors
- Antigen References
-
- Zhang X and Gao N. 2016. Small GTPases. 7:59
- Just WW and Per?nen J. 2016. Biochim Biophys Acta. 1863:1006
- Ao X, et al. 2014. Cell Death Differ. 21(3):348
- Corbier C and Sellier C. 2017. Small GTPases. 8:181
- Gene ID
- 4218 View all products for this Gene ID 17274 View all products for this Gene ID 117103 View all products for this Gene ID
- UniProt
- View information about RAB8 on UniProt.org
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