Product Details
- Verified Reactivity
- Human, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Ubqln2 recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 2.0 - 5.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2810807 (BioLegend Cat. No. 867901) AB_2810808 (BioLegend Cat. No. 867902)
Antigen Details
- Structure
- Human Ubiquilin-2 is a 624 amino acid protein with a predicted molecular mass of 65 kD and observed molecular mass of ~75 kD.
- Distribution
-
Tissue distribution: Widely expressed, highest expression in cerebellar vermis
Cellular distribution: Nucleus, cytoplasm, membrane, and autophagosome - Function
- Ubiquilin-2 plays an important role in the regulation of different protein degradation pathways including the ubiquitin-proteasome system, autophagy, and the endoplasmic reticulum-associated protein degradation.
- Interaction
- Ubiquilin-2 interacts with UBQLN1, UBE3A, BTRC, 19S proteasome subunit, C9orf72, HNRNPA1, and HNRNPU.
- Cell Type
- Neurons
- Biology Area
- Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
- Molecular Family
- Autophagosome Markers
- Antigen References
-
- Deng HX. et al. 2011. Nature. 477(7363):211-5.
- Hjerpe R. et al. 2016. Cell. 166(4):935-949.
- Wu Q. et al. 2015. Acta Neuropathol. 129(3): 417–428.
- Gene ID
- 29978 View all products for this Gene ID
- UniProt
- View information about Ubiquilin-2 on UniProt.org
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