Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial recombinant mouse SLC1A2 (EAAT2) protein (a.a. 143 - 238) with GST Tag
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10??g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2814631 (BioLegend Cat. No. 869201) AB_2814632 (BioLegend Cat. No. 869202)
Antigen Details
- Structure
- EAAT2 is a 574 amino acid protein with predicted and observed molecular mass of ~ 62 kD.
- Distribution
-
Tissue Distribution: Brain
Cellular Distribution: Plasma membrane
- Function
- EAAT2 is a sodium-dependent amino acid transporter that mediates the uptake of L-Glutamate and L- or D- aspartate.
- Interaction
- EAAT2 forms homotrimer and interacts with JUB.
- Cell Type
- Astrocytes
- Biology Area
- Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Pregnolato S, et al. 2019. Front Physiol. 10:417
- Parkin GM, et al. 2018. World J Psychiatry. 10.5498/wjp.v8.i2.51
- Rosenblum LT, Trotti D. 2017. Adv. Neurobiol. 16:117-136.
- Gene ID
- 6506 View all products for this Gene ID 20511 View all products for this Gene ID 29482 View all products for this Gene ID
- UniProt
- View information about EAAT2 on UniProt.org
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